Paraoxonase 1, hdl-cholesterol & total cholesterol in essential hypertension

Abstract

Background: - Essential hypertension (EHT) a major health problem for the world population and is universally regarded as among the strongest prognostic markers of cardiovascular disease (CVD). CVD is three times more frequent in hypertensive than in normotensive individuals and clinical manifestations are dyslipidemia. The antioxidant activity of high density lipoprotein (HDL) is a largely due to the paraoxonase 1 (PON1) located on it and PON-1 protect against atherogenesis. The present study was planned to measure the serum level of PON1 activity, high density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) in essential hypertensive patients and to compare with healthy controls. Material and methods:- In this study total 90 subjects were included above 40-65 years of age. These patients were newly diagnosed by clinicians and blood sample were collected before starting antihypertensive treatment and 30 subjects were recruited as controls. PON 1, HDL-C & TC level were measured by the spectrophotometric method, Auto Pure T HDL-C 3rd generation homogeneous assay and Wybenga & Pileggi method respectively. Data were analyzed using ‘F’ test for their level of significance. Results:- The mean PON 1 and HDL-C level were significantly lower in EHT patients as compared to the control subjects. The significant correlation was observed between the levels of PON 1 and HDL-C in essential hypertensive patients. The mean TC levels were significantly higher in patients when compared with controls. Conclusions:- Reduced serum PON 1 activity, HDL-C and elevated TC level might contribute to the increased susceptibility for the development of CVD in essential hypertension.