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Review on anti-trypanosomial drug resistance and its status in ethiopia

Authors:Walkite Furgasa, Gedamnesh Asfaw
Int J Biol Med Res. 2023; 14(4): 7692-7698  |  PDF File  |  DOI No.: 11.2023-42925575


Trypanosomosis is one of the major protozoans and neglected tropical disease that impediments to agriculture and livestock production in Africa. Even though the rapid human population increase and urbanization in sub-Saharan Africa are believed to increase the demand for livestock products. This disease negatively affects the overall development in agriculture in general and to the food self-reliance efforts of the nation in particular. Pathogenic animal trypanosomes a?ecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. Trypanosomosis is major constraint to livestock production in sub-Saharan Africa .The distribution of the disease is influenced by the existing tsetse and biting flies. Tsetse transmitted tyrpanosomosis is encountered in many part of Ethiopia. Trypanocidal drugs remain the principal method of trypanosomosis control in the country. An increasing number of reports of resistance to commonly used anti-trypanosomal drugs, indicate their future utility to be in danger. Therefore the purpose of this seminar paper is to review on anti-trypanosomal drugs and its resistance. Commonly used Anti-trypanosomal drug future effectiveness may severely reduce by widespread drug resistance. Because it is very unlikely that new anti-trypanosomal drugs will be released on to the market in the future, it is essential to maintain the efficacy of currently available drugs. So, proper detection method of drug resistance by invivo and invitro methods is very important. Resistance to one or more of the common trypanocidal drugs used in cattle has been reported in at least four regional states in Ethiopia. Exposure of parasites to sub therapeutic drug concentrations, resulting from under dosing and uncontrolled use of trypanocidal drugs, and the lack of proper diagnosis, are considered the major causes of increasing drug resistance in Ethiopia. Avoidance of under dose, use of national drug policy and allowing integrated control measure to reduce number of drug treatments when resistance detected will be strongly recommended.