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Propofol versus dexmedetomidine in reducing emergence agitation after sevoflurane anaesthesia

Authors:Anurag kondum , SS kang , Ajit Bhardwaj, Shivinder Singh
Int J Biol Med Res. 2024; 15(1): 7731-7734  |  PDF File


Propofol versus Dexmedetomidine in Reducing Emergence Agitation after Sevoflurane Anaesthesia Original Article Abstract Introduction - Emergence agitation (EA) is defined as a state of disorientation associated with confusion, restlessness, involuntary movements, and inconsolability. EA causes an increased risk of postoperative complications. This study compares the effectiveness of dexmedetomidine and propofol in preventing EA in children undergoing surgeries using sevoflurane anesthesia. Methods -This prospective randomized double-blind study was conducted from March 2022 to Oct 2023. A total of one hundred were included in the study and randomized to two groups. One group received dexmedetomidine and the other propofol to prevent EA. Pain scores, agitation scores, and sedation levels were compared as per study protocol between the two groups. Results- In our study incidence of EA was higher in the dexmedetomidine (n = 13) group in comparison to the propofol group (n = 5) (p<0.05). A significantly lower mean Observational Pain Score (OPS)was observed among the dexmedetomidine group as compared to the propofol group after extubation (p < 0.05). Also, . Post extubation mean heart rate was significantly lower in Dexmedetomidine group as compared to Propofol Group. Conclusion- Dexmedetomidine may provide significant benefits in providing post-op pain relief in comparison to propofol however incidence of emergence agitation appears to be higher with dexmedetomodine when compared to propofol as found in this study. Larger, randomized multicentre trials with appropriate sample sizes will be required to further evaluate the efficiency of these drugs in the prevention of EA.