Hepatoprotective activity on Commiphora species and its polyherbal formulation

Abstract

Background: To study the hepatoprotective effect on ethnaolic extracts of Commiphora species and its formulation on CCl4 induced severe liver damage in Wistar Albino Rats. Introduction: Commiphora berryi, C. caudata, C. pubescens (Family: Burseraceae) is an exotic indigenous in South India but has widespread distribution in many tropical and sub-tropical countries. Preliminary phytochemical evaluation of the ethanolic extract and its formulation revealed the presence of reducing sugars, flavonoids, sterols/terpenes, tannins and alkaloids. Materials and Methods: The hepatoprotective activity of ethanolic extract and its formulation of Commiphora species was studied on CCl4 induced liver toxicity in Wistar Albino rats. The activity was assessed by monitoring the various liver biomarkers viz., aspartate transaminase (AST/SGPT), alanine transaminase (ALT/SGOT), alkaline phosphatase (ALP), acid phosphatase (ACP) and total bilirubin further hepatic cells were reported by histopathological sections. Results: The Commiphora species recruited the normal value by declined the CCl4 toxic to serum concentration and also the histopathological sections and revert the intoxication to normal hepatic cells, hyperplasia and fatty changes. Conclusion: From the results, the ethanolic extracts and its formulation showed that significant (p<0.001) activity and it’s given the scientific evidences on effect of ethanolic extracts and its formulation constituting chemical compounds.