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Outcomes of superoxide solution dressings in surgical wounds: a randomized case control trial.

Authors:P K Pandey*,M Koushariya,S Shukla,S Das
Int J Biol Med Res. 2011; 2(4): 965 – 968  |  PDF File

Abstract

AIMS: This study was undertaken to evaluate the role of super-oxide solution in wound healing. At the same time an effort was made to compare the efficacy and outcomes of super-oxide solution dressings and those with povidone iodine solution. METHODS: 100 Patients in age group of 6 to 65 yrs with different types of wounds were randomized in two different groups of 50 each. Patients of group A were treated by dressing with super-oxide solution whereas those belonging to group B with povidone-iodine solution. The prospective analysis of results was done and compared in each group. RESULTS: Decrease in surface area of wounds at the ends of 1st , 2nd , 3rd and 4th weeks was more in group A when compared to group B and this was statistically significant ( p values0.005, 0.002, < 0.001 and 0.001 respectively ). No report of discontinuation in either of the groups was reported. Allergic reactions were found in one patient of group A and 2 patients in group B. The occurrence of infection in primarily sterile cases was lesser (15%) in group A than in group B (36%). Persisting infection at the end of 1st, 2nd, 3rd and 4th weeks of dressings was lower in patients of group A in comparison to group B patients. CONCLUSION: The outcome of this study supports the concept of wound healing with super oxide solution, a novel and effective mode of treatment. The efficacy of super-oxide solution in different types of wounds was found to be superior than the conventional method of treatment with povidone iodine.