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Effect of bioactive compounds and its pharmaceutical activities of sida cordifolia (linn.)

Authors:S.Sujatha and Baby Joseph, S.U. Ajisha, Satheesna Kumari
Int J Biol Med Res. 2011; 2(4): 1038 – 1042  |  PDF File

Abstract

Plants are used medicinally in different countries and are a source of many potent and powerful drugs. The general objective of this study shows to identify the bioactive compounds from the Sida cordifolia plant and to study the antimicrobial, cytotoxic effect on HeLa cell lines. The GCMS analysis results showed mainly four different compounds such as Vasicinol, Ephedrine, Vasicinone and Hypaphorine in various criteria like retention time and peak observation among the four phytochemical compounds based upon in vivo study. The agar disk diffusion method was used to study the antibacterial activity of S. cordifolia extracts against 7 bacterial strains. The Minimum Inhibitory Concentration (MIC) of the plant extracts were tested using two fold agar dilution method at concentrations ranging from 6 to 18 μm/ml. The cytotoxicity results of S. cordifolia (L.) extract on HeLa cell lines clearly reflected the treated cell lines are fortunately all the uncontrolled growth has been arrested there is declined level of cancerous cells observed. The methanol extract was found to be an effective against all phytopathogens with low MIC of 6μm/mm and the methanol extract exhibited a higher inhibition activity against Escherichia coli, Bacillus subtilis, Enterobacter aerogenes, Mycobacterium sp., and Micrococcus variance, Pseudomonas aeruginosa and B. subtilis. Meanwhile, the results also indicate the presence of major phytochemical compounds such as vasicinol, Ephedrine, vasicinone, Hypaphorine in the S. cordifolia extracts. Hence, the isolation and purification of therapeutic potential compounds from S. cordifolia could be used as an effective source against bacterial diseases in human and plants.