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The use of thyroid-stimulating hormone for description sub-clinical hypothyroidism

Authors:Fethi Abed ALGani
Int J Biol Med Res. 2011; 2(4): 1175 – 1177  |  PDF File

Abstract

Objectives: To describe the main characteristics of subclinical hypothyroidism based on thyroid-stimulating hormone screening and the related metabolic disorders. Methods: In a cross-sectional study conducted on fifty patients with Thyroid-stimulating hormone (TSH) more than 4.5 mIU/L of the reference range (0.45-4.5mIU/L), and they were not associated with clinically significant disease which had been done at laboratory in Prince Rashed Bin Al-Hassan Military Hospital, North region of Jordan in the period between October 2009 and March 2010. The data collected including age, gender, thyroid function tests, serum lipid profile, systolic blood pressure, diastolic blood pressure, pulse rate, body mass index, also concomitant goiter, hypertension and diabetes mellitus. The data were recorded and analyzed on a Statistical Package of Social Science version 10 (SPSS) computer based program. Results: The characteristics of sub-clinical hypothyroidism showed increased serum thyroid-stimulating hormone above the upper limit of the reference range with normal serum free thyroxin and free triiodothyronine concentration. The study population was older than 40 years, had more common in women, and exhibited elevated serum lipid profile, increase frequency of morbid obesity and hypertension. The concomitant goiter, diabetes and previous hypertension have found to be 28%, 50% and 54% respectively. Conclusion: To define subclinical hypothyroidism patient with serum thyroid-stimulating hormone (TSH) level outside the reference range and levels of free thyroxin (FT4) and triiodothyronine (T3) within the reference range are common in clinical practice. The necessity for further evaluation, determine risk factors and possible treatment.