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Plasma lipids and lipoproteins in selected primary school children infected with intestinal helminthiasis in a metropolitan area of southwest nigeria

Authors:Onuegbu A. Jude, Hassan A. Oladele, Olisekodiaka M Japhet, Salifu F.Fatima, Nassar, A. Sulaiman Adeyeye A. Dienye. Muhibi M.Abidemi Hassan R. Olubunmi, Okwara E John
Int J Biol Med Res. 2011; 2(4): 933 -937  |  PDF File

Abstract

Intestinal helminthes infections are most prevalent and persistent of all childhood infections. Recent studies have reported changes in lipid profile in subjects infected with helminthes and observed decreased serum lipid levels. This study was therefore carried out to determine the plasma lipids and lipoproteins in selected primary school children infected with intestinal helminthes in Oshogbo metropolis, Southwestern Nigeria. Paired samples of stool and serum of 312 children collected from three Primary Schools in Oshogbo metropolis were examined for worm egg counts using direct smear and super saturated sodium chloride floatation technique and serum lipid parameters using Randox test kit. A total of one hundred and twenty-eight (41%) of the stool samples were positive for the eggs of helminthes with 112 (35.9%) positive for the eggs of Ascaris lumbricoides while 8 (2.6%) were positive for Trichuris trichuria eggs. Only 12 (3%) had co-infection of both A. lumbricoides and T. trichuria. The mean concentrations of plasma total cholesterol(TC), high density lipoprotein – cholesterol (HDL-C) were significantly lower in the infected participants compared with the negative participants (t-value=0.57, p-value =0.014, p < 0.05). Furthermore, there was an inverse correlation between egg count per gram of stool (intestinal worm load) and the mean concentrations of plasma total cholesterol (p < 0.05); egg count per gram of stool (intestinal worm load) and high density lipoprotein cholesterol (p <0.05). We concluded that intestinal helminthes (A. lumbricoides and T. trichuria) appear to decrease plasma lipids (TC, HDL-C, TG). The mechanisms involved in the interaction between the helminthes and the biochemical parameters need further investigation as these interactions have implications on the liver functioning and hormone secretion.