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Impact of helicobacter pylori on iron deficiency anaemia in school children of age 5-12 years

Authors:UmaKiran , Suneeta Kalsurmath, Vinod Kumar CS
Int J Biol Med Res. 2011; 2(4): 1144 – 1148  |  PDF File


Background: Helicobacter pylori is the most common infection worldwide. Its prevalence is very high in developing countries. Several reports have indicated an association between H. pylori infection and anaemia, iron deficiency (ID) and iron deficiency anaemia (IDA), although the nature of interactions has not been established. Objectives: H. pylori have been established as a major cause of gastritis and peptic ulcer disease in adults and children. H. pylori infection may also have a role in the development of some extra gastrointestinal diseases, including iron deficiency anaemia. The aim of the study is to investigate the prevalence of H. pylori in iron deficiency anaemia children. Methods: A cross sectional study was conducted among 5-12y old rural school children of Jagalur, Davangere. A total of 484 children participated in the study. Blood sample was collected from each subject to measure haemoglobin and serum ferritin. H. pylori status was investigated with the 13C- Urea Breath Test. Results: Prevalence of anaemia was 30.4%. Iron-deficiency was the commonest cause occurring in 50.3% (74) children. The prevalence of H. pylori infection was 13.2%. 19% were positive for H. pylori infection in anaemic group and 10.7% in non-anaemic group. Conclusion: The present study suggests an association between H. pylori and iron deficiency anaemia. It also suggests that even asymptomatic H. pylori infection can impair the iron absorption. Along with iron supplementation, treatment for H. pylori can improve haemoglobin and serum ferritin levels.