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A comparative evaluation of combination of anorganic bone matrix (abm) / cell binding peptide (p- 15) and collagen membrane (gtr), with collagen membrane alone in human periodontal infrabony defects - a clinical and radiographic study

Authors:Priyanka G. Jaiswal , Ishan R. Tiwari , Ramesh S.Chavan , Tony Kurien J , Manohar L. Bhongade , Pankaj , Banode , Quazi Syed Zahiruddin
Int J Biol Med Res. 2012; 3(2): 1680 – 1689  |  PDF File


ABM/P-15 demonstrated true periodontal regeneration. Study aims to compare clinical and radiographic outcomes of ABM/P-15 and collagen membrane with collagen membrane alone in the treatment of infrabony defects after 6 months period. Method and Materials: Experimental study in 20 interproximal defects in 13 patients. 6 weeks after completion of basic therapy, probing pocket depth, clinical attachment level, Gingival Recession and Radiographic defect depth were recorded as baseline values. The defects were surgically accessed and debrided. The defect site in a test group were grafted with ABM/P-15+collagen membrane, in control group were grafted with collagen membrane. 6 months post-surgery, clinical and radiographic assessments for soft tissue and hard tissue were performed. Results: ABM/P-15+GTR group demonstrated significantly better mean PPD reduction of 4.74 ± 0.67 mm, CAL gain of 4.70 ± 0.79 mm, and defect fill of 4.10 ± 1.28 mm (83.33%) as compared to 3.34 ± 0.61 mm, 3.12 ± 0.75 mm, 2.90 ± 0.69 mm (62.83%) respectively in the GTR alone group. Conclusion: ABM/P-15 can be used with GTR in the treatment of infrabony defect as it resulted in a significant added benefit in terms of CAL gains, PPD reductions and radiographic defect fill compared to GTR alone.