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Heart rate variability in healthy offsprings with parental history of type 2 diabetes mellitus

Authors:Sona Bajaj, Shailaja Moodithaya , Sathees Kumar , Amrit Mirajkar, Harsha Hallahalli
Int J Biol Med Res. 2010; 1(4): 283-286  |  PDF File


Background: Children with parental history of diabetes have inherited susceptibility to develop diabetes. It has been shown that patients with type 2 diabetes mellitus (T2DM) exhibit altered autonomic activity of cardiovascular system. But a very few studies have shown early outcome of genetic transmission on cardiac autonomic activity among healthy offsprings with parental history of T2 DM. Objectives: The present study aimed to compare cardiac autonomic activity between the healthy offsprings of with and without parental history of T2 DM. Materials and Methods: 96 healthy subjects, between the age group of 18-25 years were studied. Cardiac autonomic activity was assessed by measuring spectral analysis of Heart Rate Variability (HRV). The spectral components like high frequency (HF), low frequency (LF) in absolute and normalized power were considered for analysis which reflects cardiac vagal and sympathetic activity respectively. In addition, the total power (TP) and LF/HF ratio were also considered for the analysis. Results: Mann-Whitney U test was applied to compare the cardiac autonomic modulation between the two study groups. Results of the study showed that there was no significant difference in HF and LF when expressed in both absolute and normalized units. The ratio of LF/HF, surrogate of sympathovagal balance was higher among subjects with parental history diabetes, however, statistically not significant. Conclusion: This study concludes that the parental history of diabetes does not have impact on cardiovascular autonomic activity in offsprings between the age group of 18-25 years. Further, increasing trend of sympathovagal balance among offsprings of diabetic parents as compared to subjects without parental history of diabetes indicates that follow up study might provide better understanding of alterations in cardiovascular autonomic activity in same subjects at later stages of their life.