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Assessment of parasympathetic functions in children of asthma patients

Authors:Seema Kumar Sandhya, Gupta, Sushil Dohare
Int J Biol Med Res. 2012; 3(2): 1573 – 1576  |  PDF File


Asthma patients are known to have increased cholinergic activity. This study aimed at evaluating the parasympathetic functions in children of asthma patients for any occurrence of parasympathetic over activity that is known to occur in asthmatics. The parasympathetic function tests were conducted in children between age group 5 to 10 years. The children were divided into two groups: Group I had children from non-asthmatic parents as Control Group and Group II had children from asthmatic parents as Test Group. Both the groups had healthy children showing no clinical signs and symptoms of asthma, allergy or any illness known to affect autonomic nervous system. In response to various parasympathetic function tests (S/L ratio, 30:15 ratio, valsalva ratio and tachycardia ratio) done, the two groups did not show any statistically significant dissimilarity for any of the parameters. The results of our study showed no parasympathetic over activity found in the children of asthmatic parents. Thus this study indicates that the increased cholinergic activity seen in asthmatics could be secondary to asthma and not because of autonomic aberrations inheritance in asthmatics as shown by earlier few studies supporting the possible role of inherited automatic reactivity in the pathogenesis and progression of asthma.