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Amniotic membrane dressing versus conventional dressing in lower limb varicose ulcer: a prospective comparative study

Authors:Hanumanthappa M B,Gopinathan S,Guruprasad Rai D
Int J Biol Med Res. 2012; 3(2): 1616- 1620  |  PDF File


Aim: To evaluate the safety & effectiveness of the amniotic membrane dressing in the management of varicose ulcers. Materials & Methods: A prospective comparative study was conducted in the department of surgery, A.J. hospital &research centre, India, from Jan 2010 to Jan 2012. 200 cases with leg varicose ulcers were studied, which were equally &randomly divided into control and test group. Test group received amniotic membrane dressing with compression stocking, while control group had saline dressing with compression stocking. They were evaluated on 7th, 14th & 21st day for epithelialisation, granulation tissue, control of wound infection, control of wound exudation & local pain control.Amniotic membrane grafts were prepared from placentas harvested during caesarean section after obtaining written informed consent.Results: Out of 100 cases in test group, 81 (81%) cases showed epithelialisation by the end of 3rd week (P<0.005) & in 80 % of cases, there was absence of wound infection (P<0.048). In 63 (63%) cases, significant drop in exudation was observed by the end of 1st week (P<0.034). Local pain score in test group dropped from 70 (mean) to 10 (mean). The percentage of granulation tissue increased significantly from 20% to 80% in 3 weeks time. Granulation tissue was healthy &highly vascular in the majority of the cases. No adverse effects were observed.Conclusion:Widespread availability, negligible cost, ease of use, absence of adverse effects and facilitated wound healing make amniotic membrane dressing superior to conventional dressing in the management of varicose ulcers.