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Evaluation of alkaline phosphatase in pre and post operative breast cancer patients

Authors:Prabasheela B , Baskaran S , Arivazhagan A
Int J Biol Med Res. 2012; 3(2): 1536-1537  |  PDF File


Background: Breast cancer is the commonest malignancy of women in India. Changes in serum level of some biochemical parameters before and after surgery could assess the effectiveness of surgical intervention in breast cancer patients. Objective: To assay the activity of serum Alkaline phosphatase (ALP) in patients with breast cancer before and after mastectomy. Methods: Serum Alkaline Phosphatase was assayed in 50 histopathologically proven breast cancer patients using spectrophotometric methods and compared with the age matched control. Result: The level of serum Alkaline phosphatase was significantly (p<0.05) increased in 11patients before surgery and it was decreased in 3 breast cancer patients after surgery. Conclusion: The increase in the levels of ALP may be a diagnostic marker for disease recurrence and metastases.