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Evaluation of glycated hemoglobin and microalbuminuria as early risk markers of nephropathy in type 2 diabetes mellitus.

Authors:Naveen P, Kannan N , Vamseedhar Annam , Bhanu prakash G , Aravind Kumar R
Int J Biol Med Res. 2012; 3(2): 1724 – 1726  |  PDF File


Aims: To evaluate microalbuminuria and HbA1c as early risk markers of nephropathy in Type 2 Diabetes Mellitus. To correlate microalbuminuria and HbA1c with duration of Diabetes Mellitus. Materials and Methods: The present cross-sectional study included randomly selected Uncontrolled Type 2DM [n=50], Controlled Type 2DM [n=50] and healthy controls [n=50]. Informed consent of each patient and healthy controls were taken. Complete clinical details, general physical and systemic examinations were recorded. The fasting venous blood was obtained for glycated haemoglobin and serum creatinine, while their morning urine sample was obtained for detection of microalbuminuria. Statistical analysis was done using SPSS version 16.0. One-Way ANOVA was performed. All p-values <0.05 were considered as statistically significant.Results: The mean glycated haemoglobin, microalbuminuria and serum creatinine were the highest in Uncontrolled DM [(8.01±0.83), (121±49.89), (2.18±1.12)] when compared with Controlled DM [(6.49±0.37), (47.14±39.15), 0.85±0.32] respectively. Microalbuminuria and glycated haemoglobin had a significant correlation with duration of diabetes (p<0.0001). Conclusions: The present study identifies that the risk of microalbuminuria increases with poor glycemic control. Persistent increase in glycated haemoglobin and microalbuminuria may be considered as risk markers in Diabetic Nephropathy. Therefore, regular screening for microalbuminuria and HbA1c estimation can help in clinical management to prevent complications.