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Pericardial effusion and mass : a rare presentation of chronic myelogenous leukemia.

Authors:Arti Muley, Hetal Pandya , Mahima Chajer , J D Lakhani , Chaitri Shah , Ashwin Patel
Int J Biol Med Res. 2012; 3(2): 1867 – 1869  |  PDF File

Abstract

Chronic myelogenous leukemia (CML) mostly presents as anemia, fatigue and breathlessness with hepatosplenomegaly. Pericardial involvement with effusion has been reported in acute leukemia but very rarely in CML. Only four reports of CML presenting with pericardial effusion are available till now. There is only one report of presentation with atrial mass. We present a case who presented with CML associated pericardial effusion and mass which resolved with chemotherapy with hydroxyurea. The finding becomes more important as there are recent reports of pericardial effusion being seen as adverse effect of the drugs imatinib and dasatinib. This case presented with pericardial effusion prior to starting the chemotherapy and resolved on treatment. It brings to notice a need for more research to find out the status of pericardial involvement in cases of CML and to rule out presence of pericardial effusion prior to starting treatment with imatinib and dasatinib.