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Hemtological and biochemical profile in sub lethal toxicity of cypermethrin in rats

Authors:Remya R. Nair, Mammen J. Abraham, CR Lalithakunjamma, ND Nair, CM Aravindakshan
Int J Biol Med Res. 2010; 1(4): 211-214  |  PDF File


An experiment was designed to study the hematological and biochemical changes of sub lethal repeated doses of cypermethrin . Adult Sprague Dawley rats weighing approximately 200g were used for the study. The animals were divided into five groups randomly. Group I was maintained without any treatment and group II was maintained as vehicle control. Group III to V were intoxicated with cypermethrin orally at the dose level of 40mg/kg, 80mg/kg and 120 mg/kg of body weight respectively in 2 ml gingely oil for 21 days. Hematological parameters such as packed cell volume (PCV), Hemoglobin concentration (HB), total erythrocyte count (TEC), total leukocyte count (TLC) and differential leukocyte count (DLC) were evaluated. The serum of animal was used for the assessment of biochemical parameters such as enzyme activity and serum protein content. Hematological parameters such as packed cell volume, hemoglobin concentration, total erythrocyte count and total leukocyte count showed a dose dependent reduction. The differential leukocyte count revealed lymphocytosis and neutropenia in cypermethrin intoxicated groups. Alpha cypermethrin induced elevation of serum aspartate aminotransferase(AST) and alanine aminotransferase(ALT) where as serum level of Gamma glutamyl transferase (GGT) remained unaltered.