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Effect of increase in duration of rem sleep deprivation on lipid peroxidation

Authors:Thamaraiselvi K, Mathangi DC ,Subhashini AS
Int J Biol Med Res. 2012; 3(2): 1754 – 1759  |  PDF File


Sleep deprivation is becoming common in this fast moving world. Sleep deprivation has been shown to have deleterious effect on the human body, giving rise to many diseases and disorders and REM sleep deprivation is shown to increase free radicals and cause more harm as the duration increases. The aim of this study is to assess the effect of increase in duration of REM sleep deprivation on lipid peroxidation. REM sleep deprivation cause an increase of free radical induced damage in blood. This can be shown by estimation of plasma malondialdehyde (MDA) level. Wistar strain male albino rats were used to study the effect of REM sleep deprivation. They were divided into two groups, control and REM sleep deprived. REM sleep deprivation was obtained by inverted flowerpot technique. Heparinised blood sample was taken and assessed for plasma MDA level. Body weight and food intake was monitored. The values obtained were statistically analysed using one way analysis of variance (ANOVA). On significant f test ratio, Tukey’s multiple comparison tests were also performed. The level of significance was kept at P<0.05. All the results obtained from the study are expressed as mean + standard deviation (SD). The result showed an increase in plasma MDA level as the duration of sleep deprivation increased, 48hrs (8.9* ± 2.87) and 72hrs (10.8* ± 2.4). There was only minimal change in 24hrs (7.1 ± 0.76) and 96hrs (6.4 ± 1.6) when compared to the control animals (5.4 ± 0.79) which were not significant. This increase in MDA level can be attributed to increase in free radical formation and damage, as the duration of REM sleep deprivation increases. So sleep is important in life, especially REM sleep.