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Invitro activity of combination of third and fourth generation cephalosporins along with beta lactamase inhibitors against methicillin resistant staphylococcus aureus (mrsa) and multidrug resistant gram negative bacilli.

Authors: D.Rajendra
Int J Biol Med Res. 2012; 3(3): 1998-1999  |  PDF File


A total 100 bacterial strains isolated from various clinical samples from the our hospital due to various infections of the patients admitted in our hospital. The species of Enterobacteria family like Escheria coli , Klebsiella sps. , Salmonella organisms and hospital acquired (nosocomial) infections causing by Pseudomonas aeruginosa . Staphylococcus aureus as a major organisms causing in surgical site infections, hospital admission patients, and immunocompromised patients. Which is mainly by Methicillin resistant staphylococcus aureus. These are all organisms like multidrug resistant strains of Enterobactria, Pseudomonas aeruginosa and gram positive cocci as MRSA(1) .The organisms are invitroactivity of the third and fourth generation cephalosporins combination of the beta lactamase antibiotics(3). The Himedia company available the antibiotic discs. The combination of drugs are cefeparazone+sulbactam, pipercillin+ tazobactam, ceftriaxone+tazobactam, cefepime+tazobactam tested by standard Kirby- Bauer disk diffusion technique as per CLSIs guidelines(9). Among these four agents studied , cefeparazone+sulbactam emerged as the most useful drug against to the multidrug resistance strains of Enterobacterias, Pseudomonas aeruginosa, Methicillin Resistant Staphylococcus aureus(2). The pipercillin+tazobactam are moderate useful to that particular organisms. , ceftriaxone+tazobactam, cefepime+tazobactam are poorly active against the repective organisms(8).