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Study of biochemical changes in preeclamptic women

Int J Biol Med Res. 2012; 3(3): 2025-2028  |  PDF File


Preeclampsia can be defined as a pregnancy specific condition of increased blood pressure accompanied by proteinuria, edema or both. It is a multisystem disorder characterized by endothelial cell injury which plays an important role in the pathogenesis of preeclampsia. This injury leads to various biochemical alterations. In the present study serum sodium, Uric acid, total proteins and spot urinary proteins, SBP/DBP of preeclamptic age-matched women (devoid of diabetes, UTI, renal and liver disorders) in their third trimester, as compared to their normotensive counterparts, have been measured, analyzed and compared with results of earlier studies. The preeclamptic women group exhibited highly significant change in all the parameters that were studied. Such changes in biochemical findings will lead to cardiovascular, hematological, endocrine and metabolic changes in preeclamptic patients which finally lead to end organ derangements. We suggest that preeclamptic women should be advised to have their blood pressures checked regularly to prevent future complications.