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Gastroprotective effect of aqueous extract of neem azadirachta indica on induced gastric lesion in rats.

Authors:David A. Ofusori , Benedict A. Falana , Adebimpe E. Ofusori , Taiwo A. Abayomi , Sunday A Ajayi , Gideon B Ojo
Int J Biol Med Res. 2010; 1(4): 219-222  |  PDF File

Abstract

The objective of this study was to investigate the protective effect of aqueous neem extract on ethanol-induced gastric mucosal lesions in adult wistar rats. Adult male Wistar rats used in the study were divided into 3 groups; Group A received oral normal saline and served as control; group B received 1.0ml of 50% ethanol orally every 12 hour and group C received neem extract (300 mg/kg) orally 12 hour before ethanol (50%, 1.0 ml). The experiment lasted for seven days after which the animals were sacrificed following chloroform inhalation and the stomach excised. Ethanol treated rats showed marked gross mucosal lesions in the stomach and these were characterized by multiple red patches. Histologically, ethanol treated rats showed ulcerated mucosa with marked apoptotic bodies, mucosal haemorrhage and destruction of glandular elements. Pretreatment with neem extract showed protection against ethanol-induced gastric mucosal damage. Our data suggests that pretreatment with neem extract may be useful in preventing prolonged ethanol induced gastric ulcers.