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Brucellosis: a cause for pyrexia of unknown origin

Authors:S S Mangalgi , A. G.Sajjan , S. T. Mohite
Int J Biol Med Res. 2012; 3(3): 2054-2058  |  PDF File


Introduction: Human brucellosis is an important but ignored disease in India. Due to long standing fever and lack of typical signs and symptoms, patients with acute brucellosis are often tagged as the cases of Pyrexia of Unknown Origin (PUO). Generally these patients are investigated for diverse serological tests except for brucellosis. Aims: The present study was carried out to know the prevalence of brucellosis among the PUO cases and study the clinical and epidemiological aspects of brucellosis. Materials and methods: In this cross sectional study, 2379 PUO patients were investigated for the evidence of brucellosis. Results: Among 2379 cases, 114 patients were positive by RBPT. Significant titers could be demonstrated in 105 subjects by SAT and 2-ME tests. Brucellae could be isolated from 28 cases. Along with fever, joint pain and low backache were the commonest clinical symptoms. Stay in the rural area, animal exposure and raw milk ingestion were the major risk factors. Conclusions: Brucellosis accounted for 4.41 % of PUO cases. Serological tests are more sensitive when compared to blood culture. Efforts to create awareness regarding the existence of the disease among the physicians and preventive measures to be followed in rural population are needed.