IC Value
Search
About Us
Authors
Reviewers
Editorial Board
Contact Us

Significance of early biochemical markers of atherosclerosis in subclinical hypothyroidism patients with normal lipid profile

Authors:Abhinav Kumar, Suresh , Annam V , Srikrishna R
Int J Biol Med Res. 2012; 3(4): 2483-2486  |  PDF File

Abstract

ABSTRACT Aims & Objectives: The present study was conducted to determine the significance of early novel markers of atherosclerosis in subclinical hypothyroidism patients with normal lipid profile. Materials & Methods: This study was conducted on 50 subclinical hypothyroidism patients of either sex > 18 years, and 50 age and sex matched euthyroid controls. Lipid profile, T3, T4, TSH, hs-CRP and Nitric oxide levels were estimated among both the groups. Results: TSH and hs-CRP levels were significantly increased in subclinical hypothyroidism patients compared to controls and showed a significant positive correlation. Nitric oxide levels were significantly decreased in subclinical hypothyroidism patients compared to controls and showed a significant negative correlation between TSH and Nitric oxide levels. Conclusion: This study shows an association of increased hs-CRP levels and endothelial dysfunction with progression of subclinical hypothyroidism which might be helpful to plan for levothyroxine therapy and avoid the possible future cardiovascular disease.