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Suppression of pre-term labour a comparative study between isoxsuprine and nifedipine

Authors:Seema B Nagendrappa1 . Indira Hanumaiah 2.Nandaagopal K M2.Dhananjay B Shivalingappa2. 1 Department of OBG, SDMC. Dharwad. 2 Department of OBG, SSMC & RI, TUMKUR, KARNATAKA
Int J Biol Med Res. 2012; 3(4): 2333-2336  |  PDF File


BACKGROUND: Preterm labour and delivery remains a major cause of perinatal morbidity and mortality. Tocolysis, the pharmacologic inhibition of uterine contractions, is currently the principal preterm birth preventive measure and will remain so until the aetiology of preterm labour is better understood. OBJECTIVES: To compare the tocolytic efficacy of parenteral and oral Isoxsuprine with oral Nifedipine in the suppression of preterm labour. Maternal side effects and neonatal outcome were also evaluated. METHODS: This is a prospective randomised study. 60 antenatal cases with 28-36 weeks of gestation with painful intermittent uterine contractions were considered for the study. Subjects were randomly allotted into two groups- Group A (Isoxsuprine) and Group B (Nifedipine) 30 patients each. Main outcomes include prolongation of pregnancy, maternal side effects and neonatal outcome were compared. RESULTS: Baseline characteristics were well matched in both study groups. Mean prolongation of pregnancy was 31.68 days in Nifedipine and 27.54 days in Isoxsuprine group which was statistically significant. Success rate with Nifedipine was found to be 96% as compared to Isoxsuprine which was 75%. Maternal side effects like hypotension (13.33%) and tachycardia (6.66%) were common in Isoxsuprine group, while facial flushing was seen in 16.66% patients in Nifedipine group. Neonatal outcome was similar in the both groups. CONCLUSIONS: Nifedipine is a better tolerated, more effective and safe tocolytic agent than Isoxsuprine with few maternal complications.