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Therapeutic potential of C.Zeylanicum extracts: an antifungal and antioxidant perspective

Authors:Abhay K. Pandey, Ajay Kumar Mishra, Amita Mishra, Shashank Kumar, Amita Chandra
Int J Biol Med Res. 2010; 1(4): 228-233  |  PDF File


Plants have an almost limitless ability to synthesize aromatic substances, most of which are phenols or their oxygen-substituted derivatives. These secondary metabolites could be utilized for benefit of mankind by studying their medicinal properties. Present work reports the antifungal and antioxidant activities of various bioactive fractions extracted from bark and leaves of Cinnamomum zeylanicum. Fungicidal activity of the extracts was evaluated against pathogenic and spoilage fungi, namely, Aspergillus flavus, A. fumigatus, A. niger, Penicillium spp. and Candida albicans. Many extract fractions derived from cinnamon samples exhibited low to moderate fungicidal activities. Polar fractions demonstrated comparatively better responses. Minimum fungicidal concentration (MFC) was found in the range 300 – 1000 µg/ml. The antioxidant activities of the fractions were evaluated by using reducing power assay and the results were compared with standard antioxidant ascorbic acid. Aqueous, ethanolic and acetone fractions showed appreciable reducing power. None of the fractions exerted pro-oxidant activity. The antioxidant activity increased with increasing amount of the extracts showing dose dependent response. The fungicidal and antioxidant activities may be attributed to the presence of several secondary metabolites such as phenolic and flavonoid compounds present in the extract fractions. The results obtained in the present study indicate that the bark and leaves of C. zeylanicum are potential sources of natural antimicrobial and antioxidant compounds.