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Pattern of c reactive protien in pre eclampsia and normal pregnancy

Authors:K .Omkara Murthy, R Rathod Vasantkumar, B.S. Dhananjaya,Sultana Sameena , U.N . Shobha,
Int J Biol Med Res. 2012; 3(4): 2616-2621  |  PDF File

Abstract

ABSTRACT Aim To evaluate the pattern of C reactive protein in normal pregnancy and in preeclampsia.To know the positive correlation of CRP levels to the degree of blood pressure. Objective 1. To know the variation of C reactive protein in preeclampsia and normal pregnancy. 2. To know the positive correlation of C reactive protein levels to the degree of diastolic blood pressure. Study Design This study was conducted between July 2010 to June 2012 for the period of two years. Data for the study was collected from 100 patients attending the department of Obstetrics and Gynaecology in Sri Siddhartha Medical College Hospital and Research Centre. It included 50 pregnant women with preeclampsia as cases and 50 normotensive pregnant women as controls. Venous blood samples were collected at OPD or at the time of admission. Controls were included after meeting inclusion and exclusion criteria. Study was included after meeting inclusion and exclusion criteria. Venous blood was screened for plasmatic C reactive protein latex method. Results were interpreted in positive or negative. Then Immunoturbidometric method is done to measure Creactive protein in values. Results are analysed using Chi square test, Student t test, Fisher Exact test and Fisher exact test statistics. Results Blood parameters blood urea, serum uric acid, serum creatinine, SGOT, SGPT, ALP, RBS, platelet count were significantly higher in preeclampsia compared to control group values. In the preeclampsia group CRP levels are highly increased than control group. Correlation analysis showed a strong positive correlation between serum CRP levels and diastolic blood pressure and also with urine albumin.CRP by latex method is 84.3 times more likely positive in cases than controls (p<0.001). CRP by turbidometric assay in controls Mean+/-SD 1.29+/-0.66 mg/dl. In preeclampsia mean+/-SD 4.85+/-1.45 mg/dl. Significantly higher values found in primigravida and with increase in duration of pregnancy. Conclusion Serum CRP levels increase in women with pre eclampsia. Elevated serum CRP levels in Preeclampsia were correlated with biochemical parameters of Preeclampsia. Determination of serum CRP levels may be used as a marker for the severity of Preeclampsia. Serum CRP levels are positively related to diastolic blood pressure and urinary protein excretion.